Circulating 25-Hydroxyvitamin D and Risk of Epithelial Ovarian Cancer
| Autor: | Zheng, Wei, Danforth, Kim N., Tworoger, Shelley S., Goodman, Marc T., Arslan, Alan A., Patel, Alpa V., McCullough, Marjorie L., Weinstein, Stephanie J., Kolonel, Laurence N., Purdue, Mark P., Shu, Xiao-Ou, Snyder, Kirk, Steplowski, Emily, Visvanathan, Kala, Yu, Kai, Zeleniuch-Jacquotte, Anne, Gao, Yu-Tang, Hankinson, Susan E., Harvey, Chinonye, Hayes, Richard B., Henderson, Brian E., Horst, Ronald L., Helzlsouer, Kathy J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | American Journal of Epidemiology |
| ISSN: | 1476-6256 0002-9262 |
| Popis: | A role for vitamin D in ovarian cancer etiology is supported by ecologic studies of sunlight exposure, experimental mechanism studies, and some studies of dietary vitamin D intake and genetic polymorphisms in the vitamin D receptor. However, few studies have examined the association of circulating 25-hydroxyvitamin D (25(OH)D), an integrated measure of vitamin D status, with ovarian cancer risk. A nested case-control study was conducted among 7 prospective studies to evaluate the circulating 25(OH)D concentration in relation to epithelial ovarian cancer risk. Logistic regression models were used to estimate odds ratios and 95% confidence intervals among 516 cases and 770 matched controls. Compared with 25(OH)D concentrations of 50-75 nmol/L, no statistically significant associations were observed for37.5 (odds ratio (OR) = 1.21, 95% confidence interval (CI): 0.87, 1.70), 37.5-50 (OR = 1.03, 95% CI: 0.75, 1.41), oror =75 (OR = 1.11, 95% CI: 0.79, 1.55) nmol/L. Analyses stratified by tumor subtype, age, body mass index, and other variables were generally null but suggested an inverse association between 25(OH)D and ovarian cancer risk among women with a body mass index ofor =25 kg/m(2) (P(interaction)0.01). In conclusion, this large pooled analysis did not support an overall association between circulating 25(OH)D and ovarian cancer risk, except possibly among overweight women. |
| Databáze: | OpenAIRE |
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