| Autor: |
Naoko, Okamoto, Mayumi, Homma, Yukiko, Kawaguchi, Nobuyuki, Kabasawa, Yui, Uto, Norimichi, Hattori, Shohei, Yamamoto, Eisuke, Shiozawa, Toshiko, Yamochi, Genshu, Tate, Keiichi, Isoyama, Tsuyoshi, Nakamaki, Masafumi, Takimoto |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
International journal of clinical and experimental pathology. 11(5) |
| ISSN: |
1936-2625 |
| Popis: |
Objectives: Interleukin-(IL-)17-mediated cells contribute to the imbalance of cellular immunity in the pathogenesis of immune thrombocytopenia (ITP). We examined samples of bone marrow (BM) clots to determine if IL-17-mediated immunological changes involve the BM and to identify clinical predictors of treatment response. Methods: We enrolled 33 patients with chronic ITP. BM clots were obtained before treatment and stained with the following markers: CD3, CD4, CD8, CD20, CD25, CD68, CD163, and IL-17. Pathological findings and clinical information, including laboratory data, were compared between the patients and 11 control subjects and between IL-17-high and -low-expression groups. Results: Univariate analysis revealed increased cells expressing CD68, CD163, and IL-17 in the patients with ITP than in the control subjects (P = 0.02, 0.001, and 0.001, respectively). The expression of both CD68 and CD163 showed correlation with IL-17 expression (r = 0.60 and 0.48, respectively). Responses to Eltrombopag were better in the IL-17-low-expression group than in the IL-17-high-expression group (P = 0.056). Conclusions: Macrophages and monocytes were associated with IL-17 expression in patients with ITP. We demonstrated that ITP is associated with IL-17-expressing monocytes/macrophages and might be more difficult to treat. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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