| Autor: |
N Ia, Gil'iano, G N, Bondarev, E G, Bikineeva, G I, Krasotskaia, L A, Noskin |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Radiatsionnaia biologiia, radioecologiia. 41(6) |
| ISSN: |
0869-8031 |
| Popis: |
The effects of the serin-threonin kinase inhibitor--staurosporin and inhibitor of NO-synthase--L-NAME on the radiation-induced adaptive response were studied in fibroblasts of Chinese hamster in culture. We have shown that the adaptive response as measured by the reduction of radiation-induced chromosome aberrations was completely blocked in the presence of staurosporin as well as L-NAME. These inhibitors themselves did not increase the chromosome aberration frequency when cultures were irradiated with 3 Gy alone in the presence of inhibitors. Furthermore, L-NAME noticeably decreased the gamma-rays-induced level of the chromosome aberrations. Our study confirms the participation of protein kinase C in the induction of the adaptive response and first indicates the participation of NO-synthase in this response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
