| Autor: |
S D, Iuzhakov, S D, Sokolov, S M, Vinogradova |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
Farmakologiia i toksikologiia. 51(4) |
| ISSN: |
0014-8318 |
| Popis: |
In experiments on anesthetized rats it was found that some derivatives of 2-(3-isopropylamino-2-hydroxypropoxy) phenoxymethyl isoxazole possess marked beta-adrenoblocking activity associated with alpha-adrenoblocking properties. The most active compound is 3-methyl-4-chloro-5-(3-isopropylamino-2-hydroxypropoxy) phenoxymethyl isoxazole hydrochloride (compound II) which by its beta-adrenoblocking activity is superior to propranolol, oxprenolol and especially labetalol. By its alpha-adrenoblocking activity the compound does not differ significantly from labetalol but it is inferior to phentolamine. Compound II has partial agonistic activity, exerts nonspecific membrane-stabilizing action and exhibits antifibrillatory and antiarrhythmic activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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