| Autor: |
D, Brocklehurst, A E, Champion, T R, Cheek, D G, Dewhurst |
| Rok vydání: |
1986 |
| Předmět: |
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| Zdroj: |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 7(2-3) |
| ISSN: |
1010-4283 |
| Popis: |
The value of 6-phosphogluconate dehydrogenase (6-PGDH) activity as a cytosolic marker of tumour cellularity has been assessed, together with its use as a prognostic indicator for primary breast cancer in 87 patients over 4 years. 6-PGDH activity shows a good correlation with histologically-assessed tumour cellularity in a sample of 114 patients (correlation coefficient = 0.83). Patients whose primary breast tumour had a high 6-PGDH activity showed poor relapse-free survival times when compared to those with low 6-PGDH activities (Log Rank chi 2 = 6.87, P less than 0.01). This compared with a Log Rank chi 2 of 2.22, P less than 0.20 for oestrogen positive and negative patients. These results suggest that 6-PGDH activity is a better prognostic indicator in primary breast cancer than oestrogen receptor status. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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