| Autor: |
Jian, Tang, Zhenlong, Zhou, Jun, Qian, Xiaolin, Lin, Qiwei, Liu, Qiuling, Xie, Sheng, Xiong |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Die Pharmazie. 77(2) |
| ISSN: |
0031-7144 |
| Popis: |
Psoriasis is a complex chronic skin inflammatory disease characterized by abnormal proliferation, differentiation of keratinocytes and infiltration of lymphocytes and neutrophils. The tripeptide KdPT, structurally derived from the C-terminal amino acid of alpha-melanocyte-stimulating hormone, has shown a significant anti-inflammatory effect on mild-to-moderate active ulcerative colitis in previous reports. In this research, we investigated whether KdPT could consistently ameliorate disease in a mouse model of imiquimod (IMQ)-induced psoriasis by inhibiting proliferation and inflammation response. We demonstrated that KdPT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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