[The half-life of iodine 131-labelled fibrinogen in cancer patients. Effects of heparin]

Autor: A, Boneu, J P, Armand, A, Blasco, R, Bugat, B, Boneu, H, Lucot, F, Pris, P F, Combes
Jazyk: francouzština
Rok vydání: 1976
Předmět:
Zdroj: La Nouvelle presse medicale. 5(7)
ISSN: 0301-1518
Popis: Sixty nine patients suffering from malignant tumours at different stages of their development underwent a kinetic study of fibrinogen 131I with external counting over the tumour and a study of haemostasis including P.D.F. The 1/2 T of fibrinogen 131I is shortened: 2.52 +/- 0.09 days (normal: 3.89 +/- 0.11 days.) The abnormality is proportional to serum P.D.F. levels (r=0.99). External counting demonstrated the uptake of labelled fibrinogen in the tumour. Heparine (15000 U/24h) restores the 1/2 T of fibrinogen to normal in 95 p. cent of cases. The results suggest the existence of a localised compensated intravascular coagulation process inside the tumour. Possible consequences of that phenomenon are discussed.
Databáze: OpenAIRE