Neuroprotective effects of alpha-dihydroergocryptine against damages in the substantia nigra caused by severe treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Autor:	G, Bernocchi, G, Gerzeli, E, Scherini, C, Vignola
Rok vydání:	1993
Předmět:	Male Brain Diseases Staining and Labeling Dopamine Agents MPTP Poisoning Dihydroergotoxine Axons Substantia Nigra Macaca fascicularis 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Neurofilament Proteins Glial Fibrillary Acidic Protein Animals Eosine Yellowish-(YS) Hematoxylin
Zdroj:	Acta neuropathologica. 85(4)
ISSN:	0001-6322
Popis:	The effects on the substantia nigra of alpha-dihydroergocryptine (DEK), a drug with strong dopaminomimetic activity, were tested with a severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in monkeys. Compared with monkeys treated with MPTP alone, the animals which received DEK plus MPTP showed reduced neuronal death in the substantia nigra. The reactive astrocytes were increased in number. Moreover, several axons which were immunopositive to phosphorylated neurofilament proteins and with features similar to those of control animals were seen in the pars compacta. The findings suggest that DEK preserves neuronal morphology and brain architecture.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0b7dd0a7aee7d3880a3bf05ee1bcf162 https://pubmed.ncbi.nlm.nih.gov/7683168 Zobrazit plný text záznamu Full text from SpringerLink