| Autor: |
Shuo, Pan, Gong-Chang, Guan, Ying, Lv, Zhong-Wei, Liu, Fu-Qiang, Liu, Yong, Zhang, Shun-Ming, Zhu, Rong-Huai, Zhang, Na, Zhao, Shuang, Shi, Tomohiro, Nakayama, Jun-Kui, Wang |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Oncotarget |
| ISSN: |
1949-2553 |
| Popis: |
Objectives The aim of the present study is to assess the association between the human GOSR2 gene and coronary artery disease using a haplotype-based case-control study in Chinese Han population. Methods A total of 283 coronary artery disease patients and 280 controls were genotyped for the human GOSR2 gene (rs197932, rs3785889, rs197922, rs17608766, and rs16941382). Data were analyzed for three separate groups: the total subjects, men, and women. Results For the total subjects, the frequency of the G-T haplotype established by rs3785889-rs16941382 was significantly higher in the coronary artery disease patients as compared to the control subjects (P=0.009). Multiple logistic regression analysis also confirmed that the subjects with G-T haplotype established by rs3785889-rs16941382 (homozygote) were found having significantly higher chance suffering from coronary artery disease than the ones without this haplotype (OR=1.887, P=0.007). Conclusions The G-T haplotype established by rs3785889-rs16941382 may be a risk genetic marker for coronary artery disease patients in Chinese Han population. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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