Anhedonia and depression severity dissociated by dmPFC resting-state functional connectivity in adolescents
| Autor: | Ewelina, Rzepa, Ciara, McCabe |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Brain Mapping Depressive Disorder Major Adolescent Anhedonia Depression Brain Prefrontal Cortex behavioral disciplines and activities Gyrus Cinguli Magnetic Resonance Imaging Severity of Illness Index Original Papers Nucleus Accumbens Young Adult nervous system resting-state Neural Pathways Humans biomarker DMN Female dmPFC psychological phenomena and processes |
| Zdroj: | Journal of Psychopharmacology (Oxford, England) |
| ISSN: | 1461-7285 |
| Popis: | Introduction: Given the heterogeneity within depression, in this study we aim to examine how resting-state functional connectivity (RSFC) in adolescents is related to anhedonia and depression severity on a continuum in line with the research domain criteria (RDoC) approach. Methods: We examined how RSFC in the dorsal medial prefrontal cortex (dmPFC), nucleus accumbens (NAcc) and pregenual anterior cingulate cortex (pgACC) was related to anhedonia and depression severity in 86 adolescents (13–21 years). Results: We found both anhedonia and depression severity related to decreased dmPFC RSFC with the precuneus, a part of the default mode network. However we also found that increased dmPFC connectivity with the ACC/paracingulate gyrus related to anhedonia whereas increased RSFC with the frontal pole related to depression severity. Discussion: This work extends the view that the dmPFC is a potential therapeutic target for depression in two ways: 1. We report dmPFC connectivity in adolescents; and 2. We show different dmPFC RSFC specific to anhedonia and depression severity, providing neural targets for intervention in young people at risk of depression. |
| Databáze: | OpenAIRE |
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