[An experimental study of ADP-ribosylation inhibitors as anti-influenza agents]

Autor:	V G, Vladimirov, I I, Krasil'nikov, A P, Volgarev, V G, Platonov
Rok vydání:	1991
Předmět:	Lethal Dose 50 Mice Poly Adenosine Diphosphate Ribose Orthomyxoviridae Infections Influenza A virus Benzamides Drug Evaluation Preclinical Animals Antiviral Agents
Zdroj:	Voprosy virusologii. 36(4)
ISSN:	0507-4088
Popis:	Tri-substituted benzamide derivatives are described as a new class of antiviral drugs. Three compounds (3, N-acetylaminobenzamide, 3, N-butyrylaminobenzamide, and 3-methoxybenzamide) protected mice inoculated with influenza type A virus. 3, N-acetylaminobenzamide was found to be most active. It is suggested that the antiviral effect may be due to the specific inhibitory action of these compounds on NAD(+)-dependent ADP-ribosylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0b31ccbf95e21f3dcf064c437a61a9d3 https://pubmed.ncbi.nlm.nih.gov/1796583 Zobrazit plný text záznamu