Autor: |
V V, Malinovskaia, R T, Murzabaeva, L S, Manakhova, L L, Mironova |
Rok vydání: |
1989 |
Předmět: |
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Zdroj: |
Voprosy virusologii. 34(2) |
ISSN: |
0507-4088 |
Popis: |
In clinical trials in 24 healthy volunteers of different doses of reaferon inoculated intramuscularly and intravenously for 3 days a pyrogenic reaction was observed the intensity of which depended upon the dose and route of inoculation. Reaferon exerted a dose-dependent effect on the recipient's interferon system: with large doses the interferon response of leukocytes and the capacity of lymphocytes for gamma-IF synthesis were markedly inhibited, whereas low doses (2 million IU/day) caused no significant changes. The intravenous inoculation of reaferon produced a relatively high but short-term, and the intramuscular inoculation a relatively low but of longer duration antiviral activity in the blood serum. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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