The role of systemic steroids and phototherapy in the treatment of stable vitiligo: a randomized controlled trial
| Autor: | Medhat, El Mofty, Samia, Essmat, Randa, Youssef, Sherine, Sobeih, Doaa, Mahgoub, Sherine, Ossama, Akmal, Saad, Amira, El Tawdy, Heba M, Mashaly, Iman, Saney, Rana, Helal, Olfat, Shaker |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Time Factors Adolescent Vitiligo Administration Oral Skin Pigmentation Middle Aged Intercellular Adhesion Molecule-1 Combined Modality Therapy Young Adult Treatment Outcome Pulse Therapy Drug Humans Prednisone Egypt Female Fibroblast Growth Factor 2 Ultraviolet Therapy Prospective Studies Glucocorticoids Aged Autoantibodies |
| Zdroj: | Dermatologic therapy. 29(6) |
| ISSN: | 1529-8019 |
| Popis: | Pathogenesis of vitiligo is believed to be multifactorial disease with a wide variety of therapeutic modalities. The aim of this work is to assess the efficacy of oral mini-pulse steroids (OMP) plus Nb-U.V.B in comparison to OMP alone and Nb-U.V.B alone in treating stable vitiligo. A prospective randomized controlled study including 45 patients categorized into three groups receiving therapy for 3 months; Group A received Nb-U.V.B plus OMP, Group B received OMP alone while Group C received Nb-U.V.B alone. Clinical assessment and PCR evaluation of bFGF, ICAM1, and ELISA for AMA were done. Patients receiving Nb-U.V.B plus OMP and using Nb-U.V.B alone gave statistically significant clinical response than those treated with OMP alone. Statistically significant rise of BFGF was noticed after treatment with Nb-U.V.B plus OMP and with Nb-U.V.B alone. Patients treated with OMP alone and with Nb-U.V.B alone showed statistically significant drop of ICAM-1 after therapy. NB-U.V.B plus OMP and Nb-U.V.B alone were found to be clinically superior over OMP alone in treating stable vitiligo patients, hence suggesting that adding OMP to Nb-U.V.B can maintain clinical and laboratory success for a longer period of time and with less relapse. |
| Databáze: | OpenAIRE |
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