| Autor: |
M E, Foley, H, Ryan, E, Kearney, A, Herlihy, H, Craig, P, Kelehan, E, Mooney, P, Lenehan, G, Flannelly |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Irish medical journal. 106(3) |
| ISSN: |
0332-3102 |
| Popis: |
The improved survival for bulky cervical cancers (4cm) reported with combination platinum based chemoradiation (1999) prompted a move away from surgery as these cases frequently received adjuvant radiotherapy and were exposed to the morbidity of multimodality treatment. The period pre-1999 (Group 1) was compared with post-1999 (Group 2) when chemoradiation was the preferred treatment for bulky operable cervical cancer. Significantly more cases were treated surgically among Group 1 compared with Group 2 (79% vs. 62%; P0.001). Switching from surgery to radiotherapy improved survival in both treatment categories (73% vs. 78% and 37% vs. 44%, respectively) but with no improvement in overall survival (70%/ov.s 70%). Survival (86%) was similar in both groups among surgically treated women with tumors4 cm, but significantly more in Group 2 with negative nodes received postoperative adjuvant chemoradiotherapy (Groups 1 vs. 2; 16% vs.37.5%: P0.001) and overall the surgically treated patients received more not less multimodality treatment (46.5% vs. 59%; P = 0.7). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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