| Autor: |
Yan-Jun, Wu, Kai-Hui, Wu, Rong, Jiang, Yi-Ying, Wang, Min, Luo, Qing-Qian, Xia, Cheng-Lin, Tang, Shu-Juan, Zhu, Hua-Jun, Sheng |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Zhongguo zhen jiu = Chinese acupuncturemoxibustion. 40(5) |
| ISSN: |
0255-2930 |
| Popis: |
To observe the effect of electroacupuncture (EA) on the expression of insulin phosphatidylinositol-3 kinase/glycogen synthetase kinase-3α (PI3K/GSK3α) signal pathway related proteins in the hippocampus in mice with Alzheimer's disease (AD), and to explore the regulatory mechanism of EA on improving the pathological characteristics of AD.Twelve male APP/PS1 double transgenic mice were randomly divided a model group and a treatment group, 6 mice in each group; another 6 wild-type male mice were taken as the control group. The mice in the treatment group were treated with EA (continuous wave, 2 Hz of frequency) at "Baihui" (GV 20) and bilateral "Shenshu" (BL 23), once a day; 7-day treatment was taken as a course of treatment, and 2 courses of treatment were given. The immunohistochemistry method and Western blot method were used to detect the distribution and expression level of hippocampal PI3K/GSK3α signal pathway related proteins P85α, P110α, GSK3α and pSThe proteins of P85α, P110α, GSK3α and pSEA could effectively regulate the expression of PI3K/GSK3α signal pathway related proteins in the hippocampus in mice with AD, so as to reduce the formation and deposition of SP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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