| Autor: |
Michal, Bahar, Uwe, Kordes, Tanya, Tekautz, Johannes, Wolff |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Anticancer research. 35(5) |
| ISSN: |
1791-7530 |
| Popis: |
Choroid plexus carcinomas (CPCs) are rare pediatric tumors often associated with Li-Fraumeni Syndrome (LFS), a germline mutation in the TP53 tumor-suppressor gene, predisposing to cancer.We performed a systemic literature review from 1990-2013 to evaluate the hypothesis that radiation therapy should be avoided in patients with CPC and LFS. Overall survival (OS) was compared using Kaplan-Meier curves and log-rank tests.Twenty-eight patients were documented with CPC and LFS. Eleven out of 17 patients received radiation therapy. The survival of patients receiving radiation was inferior to that of those without radiation [median (±95% confidence interval) 2-year OS=0.18 ± 0.12% versus 0.58 ± 0.12%]. The log-rank tests suggested the difference to be marginally significant (p=0.056).This finding provides evidence for pursuing treatment approaches that do not include radiation therapy for patients with LFS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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