| Autor: |
Rupesh K, Mishra, Juliane R, Sempionatto, Zhanhong, Li, Christopher, Brown, Nathalia M, Galdino, Rushabh, Shah, Shuyang, Liu, Lee J, Hubble, Kara, Bagot, Susan, Tapert, Joseph, Wang |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Talanta. 211 |
| ISSN: |
1873-3573 |
| Popis: |
Driving under the influence of cannabis and alcohol represents a major safety concern due to the synergistic or additive effect of these substances of abuse. Hence, rapid road-site testing of these substances is highly desired to reduce risks of fatal accidents. Here we describe a wearable electrochemical sensing device for the simultaneous direct, decentralized, detection of salivary THC and alcohol. The new ring-based sensing platform contains a voltammetric THC sensor and an amperometric alcohol biosensor on the ring cap, along with the wireless electronics embedded within the ring case. Rapid replacement of the disposable sensing-electrode ring cap following each saliva assay is accomplished by aligning spring-loaded pins, mounted on the electronic board (PCB), with the current collectors of the sensing electrodes. The printed dual-analyte sensor ring cover is based on a MWCNT/carbon electrode for the THC detection along with a Prussian-blue transducer, coated with alcohol oxidase/chitosan reagent layer, for the biosensing of alcohol. THC and alcohol can thus be detected simultaneously in the same diluted saliva sample within 3 min, with no cross talk and no interferences from the saliva matrix. The new wearable ring sensor platform should enable law enforcement personnel to screen drivers in a single traffic stop and offers considerable promise for addressing growing concerns of drug-impaired driving. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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