| Autor: |
Yiraldine, Herrera-Martínez, María José, Contreras González, Sergio, Pedraza-Arévalo, Maria Del Carmen, Guerrero Martínez, Ángela, Rodrigo Martínez, Alberto, González Menchen, Maria Angeles, Blanco Molina, Maria Angeles, Gálvez-Moreno, Alberto L, Moreno-Vega, Raúl M, Luque, Aura D, Herrera-Martínez |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Frontiers in endocrinology. 12 |
| ISSN: |
1664-2392 |
| Popis: |
Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal stromal tumors (GIST). We present a case report of a female patient with a 23 cm gastric GIST that expressed somatostatin-receptors and presented with severe hypercalcemia due to calcitriol secretion. Calcium control was achieved with medical treatment before the use of targeted-directed therapies. Surgery was performed and allowed complete tumor resection. Two years later, patient remains free of disease. Molecular analysis revealed the mRNA expression of 25-hydroxyvitamin D |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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