| Autor: |
Andreea, Perpelea, Andy Wiranata, Wijaya, Luís C, Martins, Dorthe, Rippert, Mathias, Klein, Angel, Angelov, Kaisa, Peltonen, Attila, Teleki, Wolfgang, Liebl, Peter, Richard, Johan M, Thevelein, Ralf, Takors, Isabel, Sá-Correia, Elke, Nevoigt |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Metabolic engineering. 69 |
| ISSN: |
1096-7184 |
| Popis: |
Pectin-rich plant biomass residues represent underutilized feedstocks for industrial biotechnology. The conversion of the oxidized monomer d-galacturonic acid (d-GalUA) to highly reduced fermentation products such as alcohols is impossible due to the lack of electrons. The reduced compound glycerol has therefore been considered an optimal co-substrate, and a cell factory able to efficiently co-ferment these two carbon sources is in demand. Here, we inserted the fungal d-GalUA pathway in a strain of the yeast S. cerevisiae previously equipped with an NAD-dependent glycerol catabolic pathway. The constructed strain was able to consume d-GalUA with the highest reported maximum specific rate of 0.23 g g |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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