| Autor: |
E N, Suspitsin, R K, Raupov, E M, Kuchinskaya, M M, Kostik |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Klinicheskaia laboratornaia diagnostika. 66(5) |
| ISSN: |
0869-2084 |
| Popis: |
Type 1 interferons (IFN1) are both key molecules of antiviral defense and potent inflammatory mediators. In 2003, increased expression of a variety of interferon 1-regulated genes was observed in a blood cells of patients with systemic lupus erythematosus (SLE). This phenomenon was called the type 1 interferon signature (IFN1-signature). Since then, expression patterns indicating the presence of an IFN1-signature were consistently detected in a range of monogenic and complex autoimmune and autoinflammatory conditions. A quantitative indicator reflecting the degree of hyperactivation of the IFN1 pathway is known as interferon score. This review discusses the possible causes of upregulated expression of interferon 1-induced genes, the laboratory approaches to the interferon score analysis, as well as the practical use of this indicator for the diagnosis of various conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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