Therapeutic high affinity T cell receptor targeting a KRAS

Autor:	Andrew, Poole, Vijaykumar, Karuppiah, Annabelle, Hartt, Jaafar N, Haidar, Sylvie, Moureau, Tomasz, Dobrzycki, Conor, Hayes, Christopher, Rowley, Jorge, Dias, Stephen, Harper, Keir, Barnbrook, Miriam, Hock, Charlotte, Coles, Wei, Yang, Milos, Aleksic, Aimee Bence, Lin, Ross, Robinson, Joe D, Dukes, Nathaniel, Liddy, Marc, Van der Kamp, Gregory D, Plowman, Annelise, Vuidepot, David K, Cole, Andrew D, Whale, Chandramouli, Chillakuri
Rok vydání:	2021
Předmět:	Proto-Oncogene Proteins p21(ras) Lung Neoplasms Receptors Antigen T-Cell Humans
Zdroj:	Nature communications. 13(1)
ISSN:	2041-1723
Popis:	Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and development of an affinity-enhanced T cell receptor (TCR) that recognizes a peptide derived from the most common KRAS mutant, KRAS
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::09b6f49fe5f2b3f9dd982b4e6d4e47e8 https://pubmed.ncbi.nlm.nih.gov/36088370 Zobrazit plný text záznamu Full text from SpringerLink