Regulation of splicing: The importance of being translatable

Autor:	MIRIAMI, ELANA, SPERLING, RUTH, SPERLING, JOSEPH, MOTRO, UZI
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	Open Reading Frames Protein Biosynthesis RNA Splicing RNA Precursors Humans RNA Messenger RNA Processing Post-Transcriptional Divergent Views Introns
Popis:	RNA sequences that conform to the consensus sequence of 5' splice sites but are not used for splicing occur frequently in protein coding genes. Mutational analyses have shown that suppression of splicing at such latent sites may be dictated by the necessity to maintain an open reading frame in the mRNA. Here we show that stop codon frequency in introns having latent 5' splice sites is significantly greater than that of introns lacking such sites and significantly greater than the expected occurrence by chance alone. Both observations suggest the occurrence of a general mechanism that recognizes the mRNA reading frame in the context of pre-mRNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::09aaff105c9aed9973bca02cef9a5611 https://europepmc.org/articles/PMC1370510/ Zobrazit plný text záznamu