| Autor: |
H P, Bartram, A, Gostner, E, Kelber, G, Dusel, W, Scheppach, H, Kasper |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Zeitschrift fur Ernahrungswissenschaft. 37 |
| ISSN: |
0044-264X |
| Popis: |
Diet-induced increases in fecal excretion of secondary bile acids (deoxy- and lithocholic acid) and certain neutral sterols (4-cholesten-3-one and 5a-cholestan-3-one) play a role in colon cancer development, whereas dietary fish oil (FO) has been implicated as a protective agent. In the present study the effects of FO and corn oil (CO) on these fecal parameters were investigated in 12 healthy volunteers consuming a low fat (30% of energy) controlled basal diet. After 4 weeks of FO supplementation (4.4 g omega-3 fatty acids/day), daily excretion of lithocholic acid showed a trend to lower values compared to CO consumption (p = 0.2), whereas other bile acids were not different during both study periods. Daily excretion of the putative colon carcinogen 4-cholesten-3-one was significantly lower in the FO compared to the CO period. This may be another biochemical mechanism by which FO exerts its protective effect on colon cancer development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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