| Autor: |
H, Behrendt, C, Charrin, B, Gibbons, C J, Harrison, J M, Hawkins, N A, Heerema, B, Horschler-Bötel, J L, Huret, J L, Laï, F, Lampert |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Leukemia. 9(1) |
| ISSN: |
0887-6924 |
| Popis: |
Fourteen cases of dic(9;12)(p11-13;p11-12) in early B-lineage acute lymphoblastic leukemia (ALL) and other hematological malignancies are reported with a review of the literature. Altogether 36 cases were collected for analysis: ALL at diagnosis (31 cases) or in relapse (one case), chronic myeloid leukemia in lymphoid blast crisis (two cases), T-cell lymphoblastic lymphoma (one case) and T-cell non-Hodgkin's lymphoma (one case). We report the first cases of dic(9;12) with a T-cell phenotype. Dic(9;12) occurs predominantly in B-progenitor ALL of childhood and young adults (age range, 1-47 years, median 12 years) but not of infancy. One or more adverse clinical features, age10 years, WBC100 x 10(9)/l, pre-B immunophenotype, platelets100 x 10(9)/l, were found in over 90% of cases. Additional structural chromosomal changes or trisomy 8 were frequently present. Nevertheless with a median follow-up of 5 years, 29/31 cases (94%) remain in first remission conferring an excellent prognosis to this leukemia. Additional cases are being sought to confirm the prognostic value of this cytogenetic aberration in various hematological malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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