Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an

Autor: Taisuke, Tawaraishi, Atsuko, Ochida, Yuichiro, Akao, Sachiko, Itono, Masahiro, Kamaura, Thamina, Akther, Mitsuyuki, Shimada, Stacie, Canan, Sanjoy, Chowdhury, Yafeng, Cao, Kevin, Condroski, Ola, Engkvist, Amanda, Francisco, Sunil, Ghosh, Rina, Kaki, John M, Kelly, Chiaki, Kimura, Thierry, Kogej, Kazuya, Nagaoka, Akira, Naito, Garry, Pairaudeau, Constantin, Radu, Ieuan, Roberts, David, Shum, Nao-Aki, Watanabe, Huanxu, Xie, Shuji, Yonezawa, Osamu, Yoshida, Ryu, Yoshida, Charles, Mowbray, Benjamin, Perry
Rok vydání: 2023
Zdroj: Journal of medicinal chemistry.
ISSN: 1520-4804
Popis: Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against
Databáze: OpenAIRE