| Autor: |
J, Poudrier, P, Graber, S, Herren, C, Berney, D, Gretener, M H, Kosco-Vilbois, J F, Gauchat |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
European journal of immunology. 30(11) |
| ISSN: |
0014-2980 |
| Popis: |
Responsiveness to IL-13 involves at least two chains, IL-4Ralpha and IL-13Ralpha1. Although mouse B cells express IL-4Ralpha, little is known about their expression of IL-13Ralpha chains. To investigate this topic further, we have generated a monoclonal antibody (C41) specific for murine IL-13Ralpha1. Using C41, IL-13Ralpha1 expression was detected on germinal center (GC) B cells by flow cytometry and immunohistochemistry. In addition, IL-13Ralpha1 was observed on follicular dendritic cells, but not interdigitating dendritic cells in the T cell areas. Furthermore, resting B cells also expressed IL-13Ralpha1, and in the presence of IL-13 produced increased amounts of IgM in response to in vitro CD40 stimulation. However, C41 was unable to neutralize this bioactivity. The distribution of IL-13Ralpha1 on murine B cells and during GC reactions suggests a role for IL-13 during B cell differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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