| Autor: |
G L, Barbour, K D, Straub, B L, O'Neal, J W, Leatherman |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Archives of internal medicine. 139(1) |
| ISSN: |
0003-9926 |
| Popis: |
Polyuria and polydipsia developed in two cases during amphotericin B therapy for deep mycoses. Neither patient could concentrate his urine in response to water deprivation or exogenous vasopressin. Other causes of vasopressin-resistant nephrogenic diabetes insipidus were not present. Three months after amphotericin B therapy had been discontinued, concentrating ability improved toward normal. A third patient was further observed and demonstrated normal diluting capacity but impaired free-water reabsorption, suggesting a distal tubular defect consistent with nephrogenic diabetes insipidus. Four months after discontinuing therapy, renal concentrating ability was normal. Amphotericin B can induce a reversible form of nephrogenic diabetes insipidus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
