Elevated progesterone-to-estradiol ratio versus serum progesterone alone for predicting poor cycle outcome with in vitro fertilization
| Autor: | Martin D, Keltz, Daniel E, Stein, Inna, Berin, Josh, Skorupski |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
endocrine system Dose-Response Relationship Drug Estradiol Pregnancy Rate Pregnancy Outcome Fertility Agents Female Fertilization in Vitro Embryo Transfer Chorionic Gonadotropin Article Pregnancy Humans Female Infertility Female hormones hormone substitutes and hormone antagonists Progesterone |
| Zdroj: | The Journal of reproductive medicine. 57(1-2) |
| ISSN: | 0024-7758 |
| Popis: | To determine whether a progesterone-to-estradiol (P/E2) ratio on day of human chorionic gonadotropin (hCG) administration would be a better predictor of in vitro fertilization (IVF) outcome than serum P alone.All 348 fresh IVF cycles performed in 2002 and 2003 at a university hospital center were reviewed for all cycle parameters as related to the peak P and peak P/E2 ration on day hCG administration.Out of the 348 cycles performed, 199 cycles resulted in clinical pregnancies. The mean P level (1.4 ng/mL) was equivalent in both conception and nonconception cycles. A P/E2 ratio1.0, however, was associated with a highly significant reduction in clinical pregnancy rate (38.2% vs. 62.6%, p0.01) and live birth rate (35.4% vs. 49.1%, p = 0.02).Cycles with elevated P/E2 ratios are associated with lower clinical pregnancy and live birth rates, which decrease further as the P/E2 ratio rises. P/E2 ratio improves the prediction of IVF outcome when compared to serum P levels alone. |
| Databáze: | OpenAIRE |
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