The safety and effectiveness of salvianolate in preventing perioperative venous thromboembolism in China
| Autor: | Chai, Yu-na, Luo, Mi, Liang, Wei-jie, Qiu, Jian-li, Li, Dangchi, Wang, Li-chong, Tu, Xing, Liu, Cheng-ye, Qin, Chong-Zhen, Li, Duo-lu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
China
Plant Extracts salvianolate Off-Label Use Venous Thromboembolism Heparin Low-Molecular-Weight meta-analysis Postoperative Complications Treatment Outcome Surgical Procedures Operative randomized controlled trial Prothrombin Time Humans Drug Therapy Combination Perioperative Period Systematic Review and Meta-Analysis Research Article Randomized Controlled Trials as Topic |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background: Salvianolate, a common drug for stabilizing heart disease and Angina Pectoris, is considered to be off-label for preventing venous thromboembolism (VTE) or anticoagulation at present. However, many clinical studies have showed that salvianolate can effectively inhibit the deep-vein thrombosis (DVT) incidence, and prevent VTE of perioperative patients in the real world in China. Objective: This analysis aimed to evaluate the effectiveness and safety of salvianolate in preventing VTE in perioperative patients. Methods: Databases of PubMed, Cochrane Library, Embase, CNKI, Wanfang and VIP were searched until July 2019. Literature retrieval, data extraction and quality assessment were independently completed by two researchers and checked with each other. Review Manager 5.2 software was applied for meta-analysis. Results: A total of 429 studies were retrieved, including 11 randomized controlled trials (RCTs) with a total of 1149 subjects. Compared with low molecular weight heparin (LMWH) group alone, salvianolate combined LMWH group had lower DVT incidence in preventing perioperative thrombosis (2.75% and 14.23%, OR: 0.21, 95% CI:[0.08,0.53]; P = .0009). The incidence of adverse reactions of experimental group was similar to that of control group (1.79% and 2.31%, OR: 0.65, 95% CI:[0.18,2.35]. P = .51). Compared with the control group, D-dimer level (D-D), platelet count (PLT), fibrinogen (FIB), whole blood high shear viscosity (WBHSV), and whole blood low shear viscosity (WBLSV) were all significantly decreased (P |
| Databáze: | OpenAIRE |
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