Shedding light on the effects of 1,25-dihydroxyvitamin D

Autor:	Arnout, Mieremet, Rianne, van Dijk, Gert, Gooris, Joke A, Bouwstra, Abdoelwaheb, El Ghalbzouri
Rok vydání:	2018
Předmět:	Calcitriol Tissue Engineering Humans Receptors Calcitriol Vitamins Epidermis Lipid Metabolism Cells Cultured Signal Transduction
Zdroj:	The Journal of steroid biochemistry and molecular biology. 189
ISSN:	1879-1220
Popis:	Human skin equivalents (HSEs) are three dimensional models resembling native human skin (NHS) in many aspects. Despite the manifold similarities to NHS, a restriction in its applications is the altered in vitro lipid barrier formation, which compromises the barrier functionality. This could be induced by suboptimal cell culturing conditions, which amongst others is the diminished activation of the vitamin D receptor (VDR) signalling pathway. The active metabolite of this signalling pathway is 1,25-dihydroxyvitamin D
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::08e8d5648eacff1f4fd2d9e142746d1e https://pubmed.ncbi.nlm.nih.gov/30711472 Zobrazit plný text záznamu Full Text from ScienceDirect