TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca
| Autor: | Riccardo, Filadi, Nuno Santos, Leal, Bernadette, Schreiner, Alice, Rossi, Giacomo, Dentoni, Catarina Moreira, Pinho, Birgitta, Wiehager, Domenico, Cieri, Tito, Calì, Paola, Pizzo, Maria, Ankarcrona |
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| Rok vydání: | 2017 |
| Předmět: |
Membrane Transport Proteins
Receptors Cell Surface Endoplasmic Reticulum Mitochondrial Membrane Transport Proteins Mitochondria Mice Inbred C57BL Mice HEK293 Cells Mitochondrial Membranes Mitochondrial Precursor Protein Import Complex Proteins Animals Humans Inositol 1 4 5-Trisphosphate Receptors Calcium Female HeLa Cells |
| Zdroj: | Current biology : CB. 28(3) |
| ISSN: | 1879-0445 |
| Popis: | The mitochondrial translocase of the outer membrane (TOM) is a protein complex that is essential for the post-translational import of nuclear-encoded mitochondrial proteins. Among its subunits, TOM70 and TOM20 are only transiently associated with the core complex, suggesting their possible additional roles within the outer mitochondrial membrane (OMM). Here, by using different mammalian cell lines, we demonstrate that TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca |
| Databáze: | OpenAIRE |
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