| Autor: |
O E, Grichenko, V V, Shaposhnikova, M Kh, Levitman, A A, Kudriavtsev, Iu N, Korystov |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Radiatsionnaia biologiia, radioecologiia. 44(1) |
| ISSN: |
0869-8031 |
| Popis: |
The radiation-induced apoptosis of thymocytes is suppressed by the common inhibitor of lipoxygenases nordihydroguaiaretic acid but not the inhibitors of cyclooxygenases or cytochrome P-450, which indicates the key role of lipoxygenases in apoptosis. However, the specific inhibitors of 5-lipoxygenase (AA861) and of 12-lipoxygenase (baicalein) do not suppress apoptosis and even enhance it. This effect can be explained by an increase in the yield of the 15-lipoxygenase product upon inhibition of 5- and 12-lipoxygenases. Indeed, the addition of 15-hydroxyecosotetraenic acid, a product of 15-lipoxygenase, into the incubation medium induces apoptosis in thymocytes. The results obtained suggest that 15-lipoxygenase is one of the enzymes involved in radiation-induced apoptosis of thymocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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