| Autor: |
R D, Santos, A P, Mansur, J, Safi Júnior, R R, Giraldez, R C, Maranhão, F, Pileggi, J A, Ramires |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Arquivos brasileiros de cardiologia. 65(2) |
| ISSN: |
0066-782X |
| Popis: |
To evaluate the effects of gemfibrozil and pravastatin in coronary artery disease patients with HDL-cholesterol (HDL-C)35 mg/dl).Twenty-nine patients (20 males, 60 +/- 9) were divided in a gemfibrozil group (G) (1200 mg/day n = 15) and a pravastatin group (P) (10 or 20 mg n = 10 and 4, respectively). The plasma lipid profile (LP) e.g. total cholesterol (TC), fractions and triglycerides (TG) was determined at 4 and 12 weeks of treatment.HDL-C was not affected in P, TC and LDL-cholesterol (LDL-C) reductions were superior to those in G (31.3% vs 13.4% and 38.7 and 11.5%, p0.05 and0.01 respectively). In G HDL-C raised by 50% (12th week p0.01). Gemfibrozil reduced TG levels in 44.7% while in P it varied -32.2% (12th week p0.01 and0.05 respectively).Gemfibrozil is more effective in reducing TG and raising HDL-C than pravastatin. On the other hand, pravastatin was more potent in reducing LDL-C levels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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