Trisomy 1q, 2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements

Autor:	Y A, Yeh, P H, Rao, C T, Cigna, W, Middlesworth, J H, Lefkowitch, V V, Murty
Rok vydání:	2001
Předmět:	Hepatoblastoma Male Chromosomes Human Pair 1 Chromosomes Human Pair 2 Karyotyping Liver Neoplasms Chromosomes Human Pair 20 Humans Infant Trisomy Translocation Genetic Chromosome Painting
Zdroj:	Cancer genetics and cytogenetics. 123(2)
ISSN:	0165-4608
Popis:	Combined cytogenetic, chromosome painting, and spectral karyotyping (SKY) analyses in a case of hepatoblastoma revealed a karyotype of 49,XY,+Y,+der(2)t(2;3)(q35;q25),der(3)t(1;3)(q12; q25),+20. Trisomy 1q, 2, and 20 identified in the present case are consistent with the previously reported cytogenetic alterations in hepatoblastoma. The breakpoints at 1q12 and 2q35 identified in this case have also been reported previously as nonrandom changes. The frequent occurrence of these rearrangements in hepatoblastoma suggests that they may be of pathogenic significance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::08990cb731372011c2bc7e23497d8a62 https://pubmed.ncbi.nlm.nih.gov/11150606 Zobrazit plný text záznamu Full Text from ScienceDirect