Classical conditioning of responses to an artificial nipple in the rat fetus: mu and kappa opioid systems

Autor:	E S, Petrov, E I, Varlinskaya, W P, Smotherman
Rok vydání:	2000
Předmět:	Rats Sprague-Dawley Embryonic and Fetal Development Behavior Animal Nipples Receptors Opioid kappa Sucking Behavior Conditioning Classical Receptors Opioid mu Animals Brain Prostheses and Implants Rats
Zdroj:	Developmental psychobiology. 37(2)
ISSN:	0012-1630
Popis:	The rat fetus exhibits oral grasp responses when presented with an artificial nipple in utero. Preexposure to milk produces a transient decrease in oral grasp responses. The effect of milk on oral grasping is mediated by endogenous activity in brain opioid systems. Specifically, milk triggers mu activity in rostral brain regions and kappa opioid activity in caudal brain regions to decrease oral grasping of the artificial nipple. Reexposure to the artificial nipple after it has been paired with milk during a classical conditioning trial results in a conditioned reduction in oral grasping that is evident when fetuses are reexposed to the nipple. The classically conditioned decrease in oral grasping is mediated by mu opioid activity in rostral brain regions and kappa opioid activity in caudal brain regions. Endogenous opioid systems, activated by exposure to milk and the nipple, may regulate the processing of sensory information during suckling in the rat.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0892d043591c96d5d6486c577fec634f https://pubmed.ncbi.nlm.nih.gov/10954831 Zobrazit plný text záznamu Plný text