| Autor: |
Breitenstein, Matthew K., Simon, Gyorgy, Ryu, Euijung, Armasu, Sebastian M., Weinshilboum, Richard M., Wang, Liewei, Pathak, Jyotishman |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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