Pharmacomodulation of 7-(2-methylene-butyryl)-2,3-dihydrobenzoxazin-[1,4]-3-one structure and normolipemic activity

Autor: Z, Moussavi, P, Depreux, D, Lesieur, N, Cotelle, J, Sauzieres, M O, Plancke, J C, Fruchart
Rok vydání: 1991
Předmět:
Zdroj: Farmaco (Societa chimica italiana : 1989). 46(2)
ISSN: 0014-827X
Popis: A series of compounds from 7-(2-methylene butyryl)-2,3-dihydro benzoxazin-[1,4]-3-one was synthesized and evaluated for its lipid lowering action in animal models. Substitutions in positions 2, 4 and 7 were performed. The results of the structure-activity relationships are very difficult to be interpreted. The different modifications tested did not show any improvement in the normolipemic activity.
Databáze: OpenAIRE