Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats

Autor:	Alexander P, Young, Jiequan, Zhu, Amina M, Bagher, Eileen M, Denovan-Wright, Susan E, Howlett, Melanie E M, Kelly
Rok vydání:	2020
Předmět:	Male Gene Knockout Techniques Vasoconstriction Animals Cerebral Arteries Receptor Endothelin B Rats Inbred F344 Rats
Zdroj:	GeroScience. 43(3)
ISSN:	2509-2723
Popis:	The human brain requires adequate cerebral blood flow to meet the high demand for nutrients and to clear waste products. With age, there is a chronic reduction in cerebral blood flow in small resistance arteries that can eventually limit proper brain function. The endothelin system is a key mediator in the regulation of cerebral blood flow, but the contributions of its constituent receptors in the endothelial and vascular smooth muscle layers of cerebral arteries have not been well defined in the context of aging. We isolated posterior cerebral arteries from young and aged Fischer 344 rats, as well as ET
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::086884d3bd7fc100883ab46f22dec438 https://pubmed.ncbi.nlm.nih.gov/33403617 Zobrazit plný text záznamu Full text from SpringerLink