| Autor: |
M J, Tsapakos, T H, Hampton, K W, Jennette |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 256(8) |
| ISSN: |
0021-9258 |
| Popis: |
DNA cross-links were found in nuclei isolated from the liver and kidney of rats treated with chromate. A dose-dependent relationship between chromate exposure and total DNA cross-links was determined using the alkaline elution technique. DNA cross-links in kidney were mainly DNA-protein in nature. Chromate also induced a small amount of interstrand DNA cross-links in kidney. Liver nuclei contained protein-associated DNA single strand breaks in addition to DNA-protein cross-links. The organotropic DNA damage induced by chromate is discussed in relation to the carcinogenicity and toxicity of chromium(VI) compounds. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
