| Autor: |
Raphaël, Bernard-Valnet, Kimberly, Berthet, Maxime, Bisseux, Brett, Broman, Samuel, Collaudin, Eléonore, Crunchant, Adèle, Dramé, Stéphanie, Efthymiou, Marianne, Entrevan, Luc, Grinand, Eirini, Kesisoglou, Johannes, Mayer, Anaïs, Oliva, Denitsa, Petkova, Stéphane, Peyrégne, Thomas, Poinsot, Annabelle, Quintavalle, Louise, Raguet, Mathilde, Règue-Guyon, Flore, Sinet, Laurent, Zablocki, Renaud, Mahieux, Hélène, Dutartre, Chloé, Journo |
| Rok vydání: |
2020 |
| Zdroj: |
Virologie (Montrouge, France). 16(6) |
| ISSN: |
1267-8694 |
| Popis: |
Innate immunity plays a critical role in the host response to a viral infection. In particular, type I interferons (IFN-I) are major effectors of antiviral innate immunity. Herein, interplays between HTLV-1 and the IFN-I response are reviewed. Particular emphasis is put on virus sensing by innate immunity receptors and on anti-HTLV-1 effects of IFN-I. We also discuss HTLV-1-induced alteration of IFN-I function and how IFN-I/AZT treatment of adult T-cell leukemia/lymphoma patients can lead to complete remission despite virus-induced escape mechanisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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