| Autor: |
Xiao-yu, Liang, Tao, Wang, Xiao-dong, Yang, Yu-jie, Qiu, Li-wei, Zhu, Peng-zhi, Wang |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. 8(1) |
| ISSN: |
1671-0274 |
| Popis: |
To study the correlation of hepatic metastasis of colorectal cancer to vascular endothelial growth factor (VEGF), angiopoietin- 2 and fibronectin (FN).The transcription and expression of VEGF, angiopoietin- 2 and FN were detected by semiquantitative reverse transcription- polymerase chain reaction (SQRT- PCR) and immunohistochemical staining in the specimens from sixty patients with colorectal cancer.The mRNA transcription and expression levels of VEGF, angiopoietin- 2 and FN in colorectal cancer tissues were obviously higher than those in paratumor normal tissues P0.05. The transcription and expression levels of VEGF were correlated with tumor invasion P0.05,Dukes' stage P0.05,and lymph node and/or hepatic metastasis P0.05. Angiopoietin expression and transcription levels were correlated with tumor differentiation. The expression of FN in extra cellular matrix (ECM) was significantly higher (P0.05),whereas ECM in basement membrane was significantly lower in cancer tissues than that in paratumor normal tissues (P0.05),which both were correlated with tumor invasion P0.05,Dukes' stage P0.05,and lymph node metastasis P0.05. Absence of FN protein in basement membrane was also correlated with hepatic metastasis.Colorectal cancer cells can secrete VEGF and contribute to metastasis and proliferation of tumor by stimulating the growth of tumor vessel. Both of VEGF and angiopoietin- 2 contribute to angiogenesis and the decrease of FN in basement membrane of cancer tissue is an important primary factor of hepatic metastasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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