[Pulmonary lymphangioleiomyomatosis (LAM). Diagnostic usefulness of immunohistochemical markers]

Autor:	R, Serrano Pardo, M T, Sotelo Rodríguez, C, Alvarez Martínez, C, Ballestin Carcavilla, E, Larrú Cabrero
Rok vydání:	1999
Předmět:	Adult Lung Diseases Biopsy Humans Female Radiography Thoracic Lymphangioleiomyomatosis Tomography X-Ray Computed Immunohistochemistry Lung Biomarkers
Zdroj:	Archivos de bronconeumologia. 34(10)
ISSN:	0300-2896
Popis:	Lymphangioleiomyomatosis (LAM) is a rare disease of unknown cause affecting the lungs of female patients. Although clinical and radiological findings may suggest LAM, a firm diagnosis is usually made after lung biopsy. Cases of LAM (histochemical diagnosis) or "suggestive of LAM" at the "12 of October" Hospital are reviewed. We applied a battery of immunohistochemical tests not used to date--involving estrogen, progesterone, desmin and HMB45 receptors--that allowed us to classify specimens as having either LAM lesions or lesions with non-LAM muscle proliferation. Smooth muscle proliferation in LAM is a distinct phenotype, such that diagnosis is facilitated by analyzing for immunohistochemical markers such as HMB45. This marker can be detected on formalin-fixed paraffin-embedded sheets in specimens obtained by either open lung or transbronchial biopsy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::07f5e07908092a0c099e379e0a462aae https://pubmed.ncbi.nlm.nih.gov/9881218 Zobrazit plný text záznamu Full Text from ScienceDirect