| Autor: |
Ying-Ying, Wu, Bei-Cai, Liu, Lian-Jin, Liu, Shi-Si, Yuan, Jie-Min, Wei, Li-Lin, Wang, Pei-Xi, Wang, Ji-Cong, Liu, Yong-Rong, Lai, Qiao-Chuan, Li |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 30(1) |
| ISSN: |
1009-2137 |
| Popis: |
To analyze the clinical characteristics of bloodstream infection (BSI) in patients treated by hematopoietic stem cell transplantation (HSCT).The clinical characteristics, distribution of pathogenic bacteria causing BSI and drug sensitivity of 910 patients treated by HSCT in our department from January 2013 to June 2020 were retrospectively analyzed.Among 910 HSCT patients, 111 patients were diagnosed as BSI within 100 days after transplantation, and 98 patients showed BSI during the period of agranulocytosis. Multivariate analysis showed that the usage of anti-thymocyte globulin (ATG), long duration of agranulocytosis and low infusion volume of mononuclear cell (MNC) were the independent risk factors affecting BSI after HSCT. Among 121 pathogenic bacteria isolated, 76 Gram-negative (GThe usage of ATG, long duration of agranulocytosis and low infusion volume of MNC are independent risk factors for BSI after HSCT. The pathogens after HSCT are mainly G- bacteria. Pseudomonas aeruginosa is highly resistant to carbapenems. Key words ;造血干细胞移植后血流感染的临床分析.分析造血干细胞移植(HSCT)患者血流感染的临床特征.回顾性分析2013年1月至2020年6月在我科行HSCT的910例患者的临床特征、发生血流感染的病原菌分布及药敏情况.910例患者中，111例在移植后100 d内确诊血流感染，98例的血流感染发生在粒细胞缺乏（粒缺）期。多因素分析显示,预处理方案含抗胸腺细胞球蛋白（ATG）、粒缺持续时间长、单个核细胞（MNC）输注量低是HSCT后血流感染的独立危险因素。分离出的121株病原菌中，革兰氏阴性（G预处理方案含ATG、粒缺持续时间长、MNC输注量低是HSCT后血流感染的独立危险因素，移植后血流感染病原菌以革兰氏阴性菌多见，铜绿假单胞菌对碳青霉烯类药物耐药率高. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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