Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives

Autor:	Jiabing, Wang, Michael J, Breslin, Paul J, Coleman, Mark E, Duggan, Cecilia A, Hunt, John H, Hutchinson, Chih-Tai, Leu, Sevgi B, Rodan, Gideon A, Rodan, Le T, Duong, George D, Hartman
Rok vydání:	2003
Předmět:	Structure-Activity Relationship Molecular Structure Adrenergic beta-Antagonists Humans Naphthyridines Integrin alphaVbeta3 Adrenergic alpha-Antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 14(4)
ISSN:	0960-894X
Popis:	A series of 3-substituted tetrahydro-[1,8]naphthyridine containing alpha(v)beta(3) antagonists was prepared. A comparison of their in vitro IC(50) values to the electron properties of the 3-substituents revealed a good linear Hammett correlation (rho=-1.96, R(2)=0.959). Electron-withdrawing groups at the 3-position of the tetrahydro-[1,8]naphthyridine decreased potency while electron-donating groups enhanced potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::07d6f59a08579d1a24dfa477b3ca3a68 https://pubmed.ncbi.nlm.nih.gov/15013021 Zobrazit plný text záznamu Full Text from ScienceDirect