| Autor: |
Gizem, Calibasi-Kocal, Ahu, Pakdemirli, Serdar, Bayrak, Nazli Mert, Ozupek, Tolga, Sever, Yasemin, Basbinar, Hulya, Ellidokuz, Turkan, Yigitbasi |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 24(4) |
| ISSN: |
2241-6293 |
| Popis: |
Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin on HCT-116 and LoVo colorectal cancer cell lines.The antiproliferative activity of 2.5-75 µM curcumin was tested on HCT-116 and LoVo colorectal cell lines and the viability of the cells was tested with WST-1 reagent by using ELISA plate reader at 450 nm. xCELLigence RTCA DP system was used for the detection of anti-invasive and anti-migrative effects of curcumin.The IC50 of curcumin was 10±0.03 for HCT-116 and 20±0.05 µM for LoVo cell lines. The IC50 of curcumin (10µM for HCT-116 and 20 µM for LoVo) showed anti-metastatic activity on these cell lines.This study showed that curcumin could be evaluated as a promising anti-cancer agent for human colorectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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