| Autor: |
I A, Vasil'eva, L N, Chernousova, A S, Zasedatelev, A Iu, Sobolev, V M, Mikhaĭlovich |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Problemy tuberkuleza. (6) |
| ISSN: |
0032-9533 |
| Popis: |
The patients with multiresistant tuberculosis were divided into 2 groups: the sensitivity of Mycobacteria tuberculosis to antituberculous drugs was evaluated in Group 1 by the methods of absolute concentrations and in Group 2 by biological microchips determining mutations in the rpo3 gene responsible for rifampicin resistance. The results of the drug sensitivity test were obtained after 3 months of treatment in Group 1 and several days prior treatment in Group 2. By taking into account the test results, reserve drugs was used in Group 2 patients. Subsequently, the results of the drug sensitivity tests carried out by the bacteriological method in Group 2 patients showed that isoniazid resistance was simultaneously noted if there were mutations in the rpo-B gene. Timely treatment with reserve drugs exhibited higher efficiency of treatment with its shorter duration in Group 2 than in Group 1. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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