| Autor: |
M, Platica, C, Bojko, R, Clincea, V, Hollander |
| Rok vydání: |
1982 |
| Předmět: |
|
| Zdroj: |
Journal of the National Cancer Institute. 68(2) |
| ISSN: |
0027-8874 |
| Popis: |
The role for lipopolysaccharide (LPS) and a pristane-induced peritoneal exudate (PIPE) on the in vitro development of murine plasmacytoma was studied. MOPC-315 cell suspensions showed little tendency for colony formation in a soft agar culture medium. Additions of LPS and PIPE were required for maximal colony formation. The LPS effect was dose-dependent down to nanogram quantities. PIPE prepared from inbred strains of mice not susceptible to pristane-induced plasmacytoma (DBA/2) or from normal peritoneal washings was ineffective. PIPE activity was radioresistant and not transferable by cell-free conditioned medium. Three strains of transplantable plasmacytomas showed colony formation stimulation by LPS plus PIPE, but LPS and PIPE were ineffective with lymphosarcoma P1798. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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