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To assess changes of nutritional status by comprehensive nutrition assessment including nutritional risk screening, dietary assessment, blood biochemical index, and body composition in acute leukemia patients who had undergone chemotherapy.A total of 169 patients with acute leukemia treated at The First Affiliated Hospital of Soochow University from June 2018 to August 2019 were recruited for this study. Before and after chemotherapy, the NRS-2002 and PG-SGA scales, dietary intake, blood biochemical index and body composition were evaluated to compare the changes of nutritional status.NRS-2002 score and PG-SGA score after chemotherapy were significantly increased than those before chemotherapy (P0.001). Many patients had insufficient nutritional intake during chemotherapy, and the dietary intake score of patients with induction chemotherapy was significantly lower than that of patients with consolidation chemotherapy (P=0.043). The results of multivariate analysis showed that induction chemotherapy was the independent risk factor for the increase of PG-SGA scores and the decrease of dietary intake (all P0.05). After chemotherapy, the white blood cell count, hemoglobin, and platelet count were significantly decreased (P0.001), the prealbumin was significantly increased (P0.001), and the blood glucose was increased (P=0.04), but albumin was not significantly changed. The weight, body mass index, fat-free mass, skeletal muscle mass and intracellular water were all significantly decreased (P0.001), and visceral fat area was increased significantly after chemotherapy (P0.05), especially in newly-diagnosed acute lymphoblastic leukemia patients after the induction of chemotherapy.The nutritional status of patients with acute leukemia has undergone significant changes after chemotherapy. A single indicator has limited significance for nutritional status assessment. Comprehensive assessment of nutritional status by multiple tools is worthy of clinical application.急性白血病患者化疗期间营养状况变化的观察研究.针对接受诱导及巩固化疗的急性白血病患者进行包含营养风险筛查、膳食评价、血生化指标监测、人体成分分析的综合营养评估，分析化疗期间营养状况变化。.纳入2018年6月至2019年8月于苏州大学附属第一医院就诊的169例急性白血病患者，化疗前后分别进行NRS-2002及PG-SGA量表评估，评估化疗过程中膳食摄入量，测定患者血常规、血生化指标，监测人体成分，从多个维度比较化疗前后营养状况的变化。.化疗后患者NRS-2002评分、PG-SGA评分较化疗前明显升高（P0.001）；化疗期间许多患者存在营养摄入不足情况，初治化疗患者膳食摄入评分明显低于巩固化疗患者（P=0.043）；多因素分析结果显示，初治诱导化疗为患者PG-SGA评分升高、膳食摄入减少的独立危险因素( 均P0.05)；患者接受化疗后，白细胞计数、血红蛋白、血小板计数较化疗前明显下降（P0.001），前白蛋白明显升高（P0.001），血糖升高（P=0.04），白蛋白水平改变不明显；患者化疗后体重、身体质量指数、去脂体重、骨骼肌质量、细胞内水分均明显下降（P0.001），内脏脂肪面积明显升高（P0.05）。这一变化在初治急性淋系白血病患者中更明显。.急性白血病患者化疗后营养状况发生了明显变化，单一指标对营养状态评估意义有限，多种工具综合评估营养状况值得在临床中推广应用。. |
