Protection against pseudorabies virus infection by intranasal vaccination of newborn pigs

Autor:	M B, McCaw, J, Xu
Rok vydání:	1993
Předmět:	Pseudorabies Time Factors Swine Body Weight Palatine Tonsil Antibodies Viral Vaccines Attenuated Herpesvirus 1 Suid Body Temperature Animals Newborn Immunoglobulin M Pseudorabies Vaccines Animals Administration Intranasal
Zdroj:	American journal of veterinary research. 54(4)
ISSN:	0002-9645
Popis:	Intranasal vaccination of newborn pigs with pseudorabies virus (PRV) strain Iowa S62/26 tk- gX- Bgal+ was evaluated to determine whether protective immunity could be stimulated in pigs given colostrum from immune sows. Three litters were vaccinated (2 litters from PRV-immune sows and 1 born to a PRV-free sow), and 2 were left as nonvaccinated controls (1 passively immune and 1 PRV-nonimmune). Pigs were then challenge-exposed at 15 weeks of age with virulent PRV strain 4892. Vaccinated pigs that suckled nonimmune sows developed serum PRV-neutralizing antibody by 15 weeks of age and did not die or have reduction in weight gain or febrile response after challenge exposure. Vaccinated pigs that suckled PRV-immune sows were seronegative for PRV at the time of challenge exposure and had less weight loss and fever than did challenge-exposed control pigs. Intranasal vaccination at birth did not stimulate adequate immunity to reduce virus shedding after challenge exposure in any of the vaccinated pigs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0737b9ec6f658d80f8b7deac79375168 https://pubmed.ncbi.nlm.nih.gov/8387249 Zobrazit plný text záznamu