| Autor: |
K, Felix, K, Kelliher, G W, Bornkamm, S, Janz |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Cancer research. 58(8) |
| ISSN: |
0008-5472 |
| Popis: |
Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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